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Microsoft Net Framework 4.5 Offline Installer For Windows 7 64 Bit [exclusive] Jun 2026

Software for motif discovery and next generation sequencing analysis

HOMER (Hypergeometric Optimization of Motif EnRichment) is a suite of tools for Motif Discovery and ChIP-Seq analysis. It is a collection of command line programs for unix-style operating systems written in mostly perl and c++. Homer was primarily written as a de novo motif discovery algorithm that is well suited for finding 8-12 bp motifs in large scale genomics data.

Hardware Requirements (recommended): 2+ Gb memory (4-8+ Gb), 10+ Gb Hard Drive space (50+ Gb)
Software Requirements: Unix compatible OS (or cygwin), perl, gcc, make, wget (optional for full functionality: R, DESeq2, blat, bedGraphToBigWig, liftOver)
License: GPLv3

HOMER works on pretty much any Linux/UNIX systems, including MacOS (if Xcode compilers are installed) and on Windows using either cygwin or a Linux subsystem.

If you are looking specifically for HOMER2, you are in the right place! HOMER2 is integrated into HOMER.

Full Program Download

Once finished, you may see a prompt to restart your computer. Click to complete the installation.

Ensure that Windows 7 Service Pack 1 (SP1) is installed. .NET Framework 4.5 is not supported on the original release of Windows 7 (without SP1).

Many applications developed between 2012 and 2020 specifically target .NET 4.5 as their minimum required version. Examples include:

The is more than a download—it is a solution to one of the most common runtime errors on legacy Windows machines. By obtaining the official, digitally signed package from Microsoft, you empower your system to run thousands of applications without nagging errors or internet dependence.

Program Components and Older Versions

Microsoft Net Framework 4.5 Offline Installer For Windows 7 64 Bit [exclusive] Jun 2026

Once finished, you may see a prompt to restart your computer. Click to complete the installation.

Ensure that Windows 7 Service Pack 1 (SP1) is installed. .NET Framework 4.5 is not supported on the original release of Windows 7 (without SP1). Once finished, you may see a prompt to restart your computer

Many applications developed between 2012 and 2020 specifically target .NET 4.5 as their minimum required version. Examples include: digitally signed package from Microsoft

The is more than a download—it is a solution to one of the most common runtime errors on legacy Windows machines. By obtaining the official, digitally signed package from Microsoft, you empower your system to run thousands of applications without nagging errors or internet dependence. Once finished, you may see a prompt to restart your computer


Update Information

Change Log - Short description of recent changes

update.txt - Current HOMER configuration list (Currently support human hg17/hg18/hg19, mouse mm8/mm9, rat rn4, X. tropicalis xenTro2, drosophila dm3, and C. elegans ce6, Zebrafish danRer7, yeast sacCer2, Arabidopsis tair10, Rice msu6, Pombe ASM294v1)
microsoft net framework 4.5 offline installer for windows 7 64 bit
Can't figure something out? Questions, comments, concerns, or other feedback:
cbenner@ucsd.edu