At 6:00 AM, the PDF ended. It didn't have a conclusion. It just had a small animation of a graduation cap throwing itself into the air.
Think of the liver as a garbage disposal. The liver chews up the drug into smaller pieces (metabolites) so the body can get rid of it. If the liver is damaged (cirrhosis), drugs stick around too long and become toxic.
To avoid errors, remember the :
: This is the safety margin of a drug. It compares the dose that produces the desired effect to the dose that could be toxic.