Sometimes it is a single SAVE.DAT .

Visit a doctor for medicine and perform your first Leap of Faith in Rome 100% Sync: Do not let Ezio's health drop below one health square Memory 2: Well Executed Objective: Track and assassinate your first official target 100% Sync: Kill the target specifically with the Hidden Blade Memory 3: New Man in Town Objective: Purchase armor and weapons to begin liberating Rome 100% Sync:

Sequence 2 is also anchored in historical accuracy. The Borgias were indeed a ruthless family, and Cesare Borgia was a charismatic, terrifying military leader. The destruction of Monteriggioni is a fictionalized event created for the game, but it mirrors the real-world aggressive expansionism Cesare employed in the Romagna region.

Sequence 2 continues Ezio’s return to Rome, focusing on rebuilding the Brotherhood and undermining Borgia control. This report summarizes objectives, key missions, collectibles, recommended approach, potential pitfalls, and save-game notes for Sequence 2 (commonly titled around "Rome — The Borgia Threat" / early Rome missions).

If your save didn’t retain progress:

The memory corridor title for the first mission of Sequence 2 is "Vilified," a word that perfectly encapsulates the mood. The sequence opens not with stealth, but with a literal bang. In a cutscene that shocked players in 2010, Cesare Borgia lays siege to Monteriggioni.

By the end of Sequence 2, you have access to the economy system. A "perfect" save at this point usually has the first few shops renovated, providing a steady stream of passive income.

If you are wary of downloading external files, you can rush to Sequence 2 in under 45 minutes. Here is the speedrun route: