Use a single FAT32 partition. Keep your WBFS files inside a wbfs folder. Modern loaders read scrubbed .wbfs files directly from FAT32. This eliminates the need for a WBFS-formatted drive entirely – and thus reduces reliance on a WBFS manager.
Even with a 64-bit version, issues can arise. Here’s how to solve them. wbfs manager 64 bits
A: No. The transfer speed to the drive is faster, but Wii load times depend on the drive’s read speed and USB 2.0 bottleneck. Use a single FAT32 partition