Season 5 is not a reboot. It is a direct continuation. Do not watch it out of order. The events reference Seasons 1-4 and The Final Break constantly.
Picking up immediately after the escape, Season 2 turns the genre on its head, transforming from a prison drama into a high-octane fugitive chase. The "Fox River Eight" are on the run, pursued by the relentless FBI Agent Alexander Mahone. prison break episodes list verified