Pda Technical Report 82 Pdf

This is where the PDF shines. If your target pH degrades your product, TR-82 validates the use of chemical chaperones (e.g., Arginine, Sucrose, or Polysorbate) added post-elution. The report provides a decision tree for determining whether to add these agents before the low pH hold (to stabilize the product) or after (to avoid protecting the virus). A critical no-go: Do not use glycine below pH 4.0, as it can catalyze aggregation.

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If you download the PDA TR-82 PDF (Technical Report No. 82, 2022), pay close attention to these four pillars: pda technical report 82 pdf