: It is most highly praised by professionals using specialized industrial or design software where the original hardware key has been lost, damaged, or is no longer supported by the manufacturer on 64-bit systems. 64 Bit Sentemul 2010 154 - Podcast on Firstory

If you are using this to protect your own software investment from hardware failure:

Since many emulators use custom drivers, you may need to boot Windows into "Test Mode."

Sentemul 2010 (64-bit) - Driver Installation Started...